He was educated at the Edinburgh Institution and then the High School in Edinburgh, and later attended University of Edinburgh. He studied for the ministry of the United Presbyterian Church of Scotland, and in 1856 was ordained pastor of the Greyfriars church, Glasgow. He also examined in mental philosophy for the University of Glasgow from 1861 to 1864, and from 1866 conducted the moral philosophy classes at that university, until in 1868 he became Professor of Moral Philosophy at Edinburgh, holding this post until his death 29 years later. He was made LL.D. of Glasgow in 1865. At this point the family lived at 197 St Vincent Street.
In 1869 he was elected a Fellow of the Royal Society of Edinburgh his proposer being John Hutton Balfour. His address was then given as Craigrowan, a large villa in Merchiston on the west side of the city.
His first and most famous work was The Philosophy of the Infinite (1854), in which he attacked the statement of Sir William Hamilton that we can have no knowledge of the Infinite. Calderwood maintained that such knowledge, though imperfect, is real and ever-increasing; that Faith implies Knowledge. His moral philosophy is in direct antagonism to Hegelian doctrine, and endeavours to substantiate the doctrine of divine sanction. Beside the data of experience, the mind has pure activity of its own whereby it apprehends the fundamental realities of life and combat. He wrote in addition A Handbook of Moral Philosophy, On the Relations of Mind and Brain, Science and Religion, The Evolution of Man's Place in Nature.
Among his religious works the best-known is his Parables of Our Lord, and just before his death he finished a Life of David Hume in the Famous Scots Series. His interests were not confined to religious and intellectual matters; as the first chairman of the Edinburgh school board, he worked hard to bring the Education Act into working order. He published a well-known treatise on education. In the cause of philanthropy and temperance he was indefatigable. In politics he was at first a Liberal, but became a Liberal Unionist at the time of the Home Rule Bill.
He is buried in Morningside Cemetery, Edinburgh, towards the south-west. His wife Anne Hutton Leadbetter (d.1912) lies with him.
He married Anne Hutton Leadbetter in 1857.
- "Overview, Henry Calderwood, (1830—1897) philosopher". Oxford Index. Oxford University Press. 2014. Retrieved 28 July 2015.
- Gilbert, W.M., editor, Edinburgh in the Nineteenth Century, Edinburgh, 1901:183
- Glasgow Post Office Directory 1865-6
- "List of the Ordinary Fellows of the Society". Transactions of the Royal Society of Edinburgh. 26: xi–xiii. 1870. doi:10.1017/S008045680002648X.
- Livingstone, David N. (2009). Evolution and Religion. In Michael Ruse; Joseph Travis. Evolution: The First Four Billion Years. Harvard University Press. p. 357. ISBN 978-0-674-03175-3
- Lundin, Roger. (2013). Christ Across the Disciplines: Past, Present, Future. Wm. B. Eerdmans Publishing Co. p. 95. ISBN 978-0-8028-6947-0
- Biography of Calderwood published in 1900 by his son William Leadbetter Calderwood and the Rev. David Woodside, with a chapter on his philosophy by A. S. Pringle-Pattison
- Calderwood, Henry (1881). The Relations of Science and Religion. Macmillan (reissued by Cambridge University Press, 2009; ISBN 978-1-108-00015-4)
- public domain: Chisholm, Hugh, ed. (1911). "Calderwood, Henry". Encyclopædia Britannica (11th ed.). Cambridge University Press. This article incorporates text from a publication now in the